Coronavirus

SARS-CoV-2 is a new type of coronavirus, which began to spread in December 2019 from Wu-han, China. It causes an infectious disease called COVID-19. The virus is able to propagate from human to human and spreads through air droplets during coughing, sneezing or body contact.

The new type of virus spreads quickly. According to preliminary data, one patient causes an infection of other 2-3 people on average. The disease is unfortunately connected to high mortality rate. Some studies suggest the mortality rate is between 2 and 7% of patients.

Signs of coronavirus infection

The disease can be symptomless or just like a common cold. However, it can also be severe or even fatal. The most common signs of infection are fever (88%), dry cough (68%), shortness of breath (18%), fatigue, sore throat, migraine and muscle aches (14%). Less common symptoms are chills (11%), nausea and vomitus (5%) or diarrhea (4%). Rhinitis is an unusual sign.

According to the available data, the incubation period takes up to 2 weeks. However, it can be significantly shorter. It cannot be ruled out that the symptoms may appear as early as 24 hours after infection.

Examination possibilities

Since May 2020, we have been offering not only antibodies tests but also the RT-PCR nasopharyngeal test of coronavirus presence in nasopharynx.

The PCR method is used to detect the presence of the virus in the nasopharynx, so it is suitable for acute problems. At the same time, it is the only proven method of non-infectivity detection. The PCR test will therefore be used to confirm (or rule out) the infectivity, for example when traveling abroad or vice versa.

The antibody test method is used to determine your body's immune response against a new type of coronavirus. The examination will tell you if you have encountered the virus in the past and, if so, what stage of the infection you are in. It is therefore appropriate after a longer period of time from the potential infection (2-3 weeks).

Examination using RT-PCR method

The PCR method (polymerase chain reaction) is able to detect the genetic information of the virus in a sample. It is therefore independent on the body's response to the virus and can detect SARS-CoV-2 with high accuracy. It is also the right method for non-infectivity confirmation when traveling abroad or returning from abroad, right now.

Slightly less pleasant but the more secure method of collection is through the nose: the wire is bent by the tube to an angle of 120° (be careful not to touch the wire with anything other than the inside of the tube), insert deep into the nose (at least 4 cm), using slight pressure wipe the back wall of the nasopharynx.

The second option is through the mouth: the wire is bent by the tube to an angle of 90°, lead it through the mouth beyond the tonsils, wiping the back wall of the nasopharynx (directly opposite you behind the tonsils), so that the entire brush touched just rear walls. When taking the sample, it is important to avoid the tongue and other mucous membranes on the sides.

We'll let you know the test result as soon as we can. The cooperating laboratory guarantees a 72-hour interval. In absolute majority of cases, we manage to get the results the second day after examination.

Simply, yes. If your test is negative, you will receive a certificate of non-infectivity from a doctor.

Antibodies test

The test takes the form of capillary blood collection (finger prick), which is minimally painful and almost non-invasive. After applying the blood to the test kit from the American manufacturer, we know the result in a short time.

The test is suited for anyone who wants to know if he/she was infected with the SARS-CoV-2 virus in the past. It allows you to assess the stage of the disease and estimate the time of infection or prognosis for the future. You will find out if you have long-term immunity to a new type of coronavirus and if you need to worry about future infections. According to the methodology of the Ministry of Health, it is also used to end a two-week quarantine after returning from abroad (if the patient did not have a positive PCR test). The great advantage of the test is the assessment of the patient's stage of the disease, as IgM antibodies are rapid and their levels in the body soon fall to zero, while IgG antibodies are long-lasting and persist in the body for many weeks, probably months.

No existing test or laboratory method can achieve 100% detection of SARS-CoV-2. Unfortunately, every laboratory measurement is prone to systematic, statistical or gross errors. Every device has its limitations, every collection of biological material is accompanied by a possible human error in case of poor collection.

The advantage of our cassette test for antibody testing over PCR testing for direct virus detection is the fact that antibody testing is performed from capillary blood and the possibility of poor sampling is thus minimized. Antibodies are present in the blood when immunity is created. Conversely, in the case of direct virus detection by PCR, nasopharyngeal sampling must be performed, which may not be successful and may not detect a new type of coronavirus, eg due to insufficient depth of the nasopharyngeal sampling.

According to the US manufacturer, our antibody test has the following parameters:

For the IgG antibody class
sensitivity = 100% (95% confidence interval: 86-100%)
specificity = 98% (95% confidence interval: 90-100%)
accuracy = 99% (95% confidence interval: 92-100%)

For the IgM class of antibodies
sensitivity = 85% (95% confidence interval: 62-97%)
specificity = 96% (95% confidence interval: 86-100%)
accuracy = 93% (95% confidence interval: 84-98%)

By combining the examination of both classes of antibodies, we multiply the sensitivity, specificity and accuracy of this test and achieve very good results in the examination. However, it should be noted that the formation of antibodies, according to available data, occurs up to about 2-3 weeks after infection, in other words 1-2 weeks from the first symptoms. The great advantage of the test is the assessment of the patient's stage of the disease, as IgM antibodies are rapid and their levels in the body soon drop to zero, while IgG antibodies are long-lasting and persist in the body for many weeks, probably months.

Yes, the test is specific to the SARS-CoV-2 virus, which causes a disease known as COVID-19, which has caused the current global pandemic.

The test allows the determination of IgM and IgG antibodies, which inform you about the disease and the development of immunity based on (not only symptomatic) infection. Your immune system produces these basic types of antibodies in a viral infection - IgM (acute), IgG (long-term).

High IgM levels without IgG indicate that your body is currently battling an acute coronavirus infection.

High levels of both types of antibodies indicate the next stage of the disease, when your immune system is already effectively fighting with the infection.

High IgG levels without IgM mean that your body was infected with this infection long time ago, and your immunity is likely to defend itself the next time you encounter the virus.

Absence of antibodies means that your immune system has not yet encountered coronavirus or that the infection occurred less than 1 to 2 weeks before testing.

Yes, the tests we use are CE IVD certified, which means they are approved for use in EU countries.

You will get to know the results of the antibody test approximately 10 to 15 minutes after capillary blood collection.

Results

If you experience symptoms of the disease, contact your GP. If you are asymptomatic, be careful and continue to follow state hygiene guidelines.